The work of our lab is interdisciplinary and draws on an extensive network of collaborators from different disciplines.
Complete Directory
All our publications and articles, listed and classified below, are also available for consultation on the platform of the National Library of Medicine / Pub Med (click on the associated links for more details).
DIRECT ACCESS TO A CATEGORY ON THE LISTING:
Selected original publications
10/09/2025
Sharma SD, Hum RM, Nair N, Marshall L, Storrie A, Bowes J, MacGregor A, Yates M, Morris AP, Verstappen S, Barton A, van Steenbergen H, Knevel R, van der Helm-van Mil A, Viatte S.
Systematic review and independent validation of genetic factors of radiographic outcome in rheumatoid arthritis identifies a genome-wide association with CARD9.
Ann Rheum Dis. 2025 Sep;84(9):1469-1483.
Impact: the Viatte lab, working with our international collaborators, has conducted a systematic review and validation of all know genetic associations with disease severity in rheumatoid arthritis outside the HLA and demonstrated that very few genetic determinants of disease susceptibility are shared with genetic determinants of disease outcome. This finding supports the principle that different genetic factors underlie transition to different clinical stages of autoimmune diseases. This contribution has important implications for the choice of genetic markers to include in the calculation of Polygenic Risk Scores (PRS) for stratified medicine in general.
26/06/2025
Yap CF, Nair N, Sharma SD, Bowes J, Ariff ABM, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Verstappen S, Bluett J, Morris AP, Barton A, Plant D*, Viatte S*. *Equal contributions
Comparative Effectiveness of Abatacept versus Adalimumab in Shared Epitope positive and negative Rheumatoid Arthritis patients.
Arthritis Rheumatol. 2025 Jun 26. doi: 10.1002/art.43298. Online ahead of print.
Impact: this study, co-led with Darren Plant and funded by our industrial partner Bristol Myers Squibb, represents an important step in assessing the potential of genetic stratification for patients with rheumatoid arthritis. We confirm that genetic factors located within the HLA are associated with response to treatment, but we show that this association is not treatment-specific, and therefore cannot be used in a clinical setting to stratify patients into treatment response categories.
28/04/2015
Viatte S, Plant D, Han B, Fu B, Yarwood A, Thomson W, Symmons DPM, Worthington J, Young A, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Raychaudhuri S, Barton A.
Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.
JAMA. 2015 Apr 28;313(16):1645-56.
Editorial in JAMA: “The genetics of rheumatoid arthritis: new insights and implications.” Felson DT, Klareskog L. JAMA. 2015 Apr 28;313(16):1623-4.
Highlight in Nat Rev Rheumatol: “Genetics: Beyond susceptibility–predictors of prognosis and response in RA.” Barranco C. Nat Rev Rheumatol. 2015 Jul;11(7):383.
10/12/2012
Viatte S, Plant D, Bowes J, Lunt M, Eyre S, Barton A, Worthington J.
Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients.
Ann Rheum Dis. 2012 Dec;71(12):1984-90.
Impact: This was the first systematic study conducted across all known genetic markers of rheumatoid arthritis susceptibility to show that some of these markers are shared, while others are specific to different serotypes of rheumatoid arthritis (heterogeneity).
Reviews
From the lab
10/06/2025
Marshall L, Raychaudhuri S, Viatte S.
Understanding rheumatic disease through continuous cell state analysis.
Nat Rev Rheumatol. 2025 Jun;21(6):323-335.
10/12/2024
Sharma SD, Leung SH, Viatte S.
Genetics of rheumatoid arthritis.
Best Pract Res Clin Rheumatol. 2024 Dec;38(4):101968.
CONTRIBUTIONS OF GENETICS IN RHEUMATOID ARTHRITIS
02/10/2019
Mulhearn B, Barton A, Viatte S.
Using the Immunophenotype to Predict Response to Biologic Drugs in Rheumatoid Arthritis.
J Pers Med. 2019 Oct 2;9(4).
10/06/2017
Viatte S, Barton A.
Genetics of rheumatoid arthritis susceptibility, severity, and treatment response.
Semin Immunopathol. 2017 Jun;39(4):395-408.
10/03/2013
Viatte S, Plant D, Raychaudhuri S.
Genetics and Epigenetics of Rheumatoid Arthritis.
Nat Rev Rheumatol., 2013 Mar;9(3):141-53.
10/12/2012
Viatte S, Barton A.
The Role of Rheumatoid Arthritis Genetic Susceptibility Markers in the Prediction of Erosive Disease.
European Musculoskeletal Review, 2012;7(2):102–7.
31/10/2007
Viatte S, Waeber G, Vollenweider P.
Some less well known side effects of glucocorticoids: specific prevention and treatment?
Rev Med Suisse. 2007 Oct 31;3(131):2472-4, 2476-7.
10/06/2006
Viatte S, Alves PM, Romero P.
Reverse immunology approach for the identification of CD8 T-cell-defined antigens: advantages and hurdles.
Immunol Cell Biol. 2006 Jun;84(3):318-30.
Collaborations
30/09/2025
Hum RM, Christofi M, Smith SL, Marshall LM, Plant D, Viatte S, Ho P, Martin P, Barton A.
Synovial immunopathology in psoriatic arthritis: cellular and molecular insights.
Lancet Rheumatol. 2025 Nov;7(11):e808-e822. doi: 10.1016/S2665-9913(25)00231-0. Epub 2025 Sep 30.
Original research article from the lab
22/05/2024
Kovalenko A, Viatte S.
Development and application of EpitopeScan, a Python3 toolset for mutation tracking in SARS-CoV-2 immunogenic epitopes.
Front Immunol. 2024 May 22;15:1356314.
05/05/2023
Mulhearn B, Marshall L, Sutcliffe M, Hannes SK, Fonseka C, Hussell T, Raychaudhuri S, Barton A, Viatte S.
Automated clustering reveals CD4+ T cell subset imbalances in rheumatoid arthritis.
Front Immunol. 2023 May 5;14:1094872.
25/04/2022
Sharma S, Plant D, Bowes J, Macgregor A, Verstappen S, Barton A, Viatte S.
HLA-DRB1 haplotypes predict cardiovascular mortality in inflammatory polyarthritis independent of CRP and anti-CCP status.
Arthritis Res Ther. 2022 Apr 25;24(1):90.
10/07/2016
Viatte S, Massey J, Bowes J, Duffus K; arcOGEN Consortium, Eyre S, Barton A, Worthington J.
Replication of genetic loci outside the HLA conferring susceptibility to anti-CCP negative rheumatoid arthritis.
Arthritis Rheumatol. 2016 Jul;68(7):1603-13.
06/06/2016
Ling SF*, Viatte S*, Lunt M, Van Sijl AM, Silva-Fernandez L, Symmons DP, Young A, Macgregor AJ, Barton A. *Joint first authors
HLA-DRB1 amino acid positions 11/13, 71 and 74 are associated with inflammation level, disease activity and the Health Assessment Questionnaire disability index in patients with inflammatory polyarthritis.
Arthritis Rheumatol. 2016 Jun 6. doi: 10.1002/art.39780.
23/05/2016
Viatte S*, Lee JC*, Fu B, Espéli M, Lunt M, De Wolf JN, Wheeler L, Reynolds JA, Castelino M, Symmons DP, Lyons PA, Barton A, Smith KG. * Joint first authors
Genetic variation in FOXO3 is associated with reductions in inflammation and disease activity in inflammatory polyarthritis.
Arthritis Rheumatol. 2016 May 23. doi: 10.1002/art.39760.
10/07/2014
Viatte S, Yarwood A, McAllister K, Al-Mudhaffer S, Fu B, Flynn E, Symmons DP, Young A, Barton A.
The role of genetic polymorphisms regulating vitamin D levels in rheumatoid arthritis outcome: a Mendelian randomisation approach.
Ann Rheum Dis. 2014 Jul;73(7):1430-3.
10/02/2013
Viatte S*, Plant D*, Lunt M, Fu B, Parker B, Galloway J, Solymossy C, Worthington J, Symmons D, Dixey J, Young A, Barton A. *Joint first authors
Investigation of rheumatoid arthritis genetic susceptibility markers in the Early Rheumatoid Arthritis Study (ERAS) provides further replication of the TRAF1 association with radiological damage.
J Rheumatol., 2013 Feb;40(2):144-56.
03/11/2012
Viatte S, Flynn E, Lunt M, Barnes J, Singwe-Ngandeu M, Bas S, Barton A, Gabay C.
Investigation of Caucasian rheumatoid arthritis susceptibility loci in African patients with the same disease.
Arthritis Res Ther. 2012 Nov 3;14(6):R239.
09/05/2012
Burr ML*, Viatte S*, Bukhari M, Plant D, Symmons DPM, Thomson W**, Barton A**. *Joint first authors /**Joint senior authors
Long-term stability of anti-cyclic citrullinated peptide antibody status in patients with early inflammatory polyarthritis.
Arthritis Res Ther. 2012 May 9;14(3):R109.
Original research article (collaborations)
10/10/2025
Al-Janabi A, Martin P, Simpson C, Rhys H, Khan AR, Eyre S, Christofi M, Foulkes AC, Skelton A, Viatte S, Barton A, Morris AP, Smith CH, Griffiths CEM, Warren RB.
Blood Single-Cell Transcriptomic and Proteomic Signatures of Paradoxical Eczema in Patients with Psoriasis Treated with Biologics.
J Invest Dermatol. 2025 Oct;145(10):2535-2548.
10/05/2024
Hum RM, Sharma SD, Stadler M, Viatte S, Ho P, Nair N, Shi C, Yap CF, Soomro M, Plant D, Humphreys JH, MacGregor A, Yates M, Verstappen S, Barton A, Bowes J; all NOAR collaborators.
Using polygenic risk scores to aid diagnosis of patients with early inflammatory arthritis: results from the Norfolk Arthritis Register.
Arthritis Rheumatol. 2024 May;76(5):696-703.
10/05/2023
Smith SL, Alexander S, Nair N, Viatte S, Eyre S, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Plant D, Barton A.
Pre-treatment calprotectin (MRP8/14) provides no added value to testing CRP alone in terms of predicting response to TNF inhibitors in rheumatoid arthritis in a post hoc analysis.
Ann Rheum Dis. 2023 May;82(5):611-620.
28/11/2022
Sutcliffe M, Nair N, Oliver J, Morgan AW, Isaacs JD, Wilson AG, Verstappen SMM, Viatte S, Hyrich KL, Morris AP, Barton A, Plant D.
Pre-defined gene co-expression modules in rheumatoid arthritis transition towards molecular health following anti-TNF therapy.
Rheumatology (Oxford). 2022 Nov 28;61(12):4935-4944.
10/11/2022
Ishigaki K, Sakaue S, Terao C, Luo Y, Sonehara K, Yamaguchi K, Amariuta T, Too CL, Laufer VA, Scott IC, Viatte S, Takahashi M, Ohmura K, Murasawa A, Hashimoto M, Ito H, Hammoudeh M, Emadi SA, Masri BK, Halabi H, Badsha H, Uthman IW, Wu X, Lin L, Li T, Plant D, Barton A, Orozco G, Verstappen SMM, Bowes J, MacGregor AJ, Honda S, Koido M, Tomizuka K, Kamatani Y, Tanaka H, Tanaka E, Suzuki A, Maeda Y, Yamamoto K, Miyawaki S, Xie G, Zhang J, Amos CI, Keystone E, Wolbink G, van der Horst-Bruinsma I, Cui J, Liao KP, Carroll RJ, Lee HS, Bang SY, Siminovitch KA, de Vries N, Alfredsson L, Rantapää-Dahlqvist S, Karlson EW, Bae SC, Kimberly RP, Edberg JC, Mariette X, Huizinga T, Dieudé P, Schneider M, Kerick M, Denny JC; BioBank Japan Project; Matsuda K, Matsuo K, Mimori T, Matsuda F, Fujio K, Tanaka Y, Kumanogoh A, Traylor M, Lewis CM, Eyre S, Xu H, Saxena R, Arayssi T, Kochi Y, Ikari K, Harigai M, Gregersen PK, Yamamoto K, Louis Bridges S Jr, Padyukov L, Martin J, Klareskog L, Okada Y, Raychaudhuri S.
Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.
Nat Genet. 2022 Nov;54(11):1640-1651.
01/03/2019
Hensor EMA, McKeigue P, Ling SF, Colombo M, Barrett JH, Nam JL, Freeston J, Buch MH, Spiliopoulou A, Agakov F, Kelly S, Lewis MJ, Verstappen SMM, MacGregor AJ, Viatte S, Barton A, Pitzalis C, Emery P, Conaghan PG, Morgan AW.
Validity of a two-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis.
Rheumatology (Oxford). 2019 Mar 1.
03/10/2017
Correa-Rodríguez M, Viatte S, Massey J, Schmidt-RioValle J, Rueda-Medina B, Orozco G.
Analysis of SNP-SNP interactions and bone quantitative ultrasound parameter in early adulthood.
BBMC Med Genet. 2017 Oct 3;18(1):107.
13/07/2017
Wei WH, Viatte S, Merriman TR, Barton A, Worthington J.
Genotypic variability based association identifies novel non-additive loci DHCR7 and IRF4 in sero-negative rheumatoid arthritis.
Sci Rep. 2017 Jul 13;7(1):5261.
03/12/2016
Jiang X, Askling J, Saevarsdottir S, Padyukov L, Alfredsson L, Viatte S, Frisell T.
A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy – results from a Swedish cohort study.
Arthritis Res Ther. 2016 Dec 3;18(1):288.
24/04/2016
Wei WH, Bowes J, Plant D, Viatte S, Yarwood A, Massey J, Worthington J, Eyre S.
Major histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis.
Sci Rep. 2016 Apr 25;6:25014. doi: 10.1038/srep25014.
10/11/2015
Ibrahim I, Humphreys J, Mokhtar I, Marshall T, Verstappen S, Symmons D, Viatte S, Barton A, Plant D.
Association of chemokine CXC ligand 12 gene polymorphism (rs1746048) with cardiovascular mortality in patients with rheumatoid arthritis: results from the Norfolk Arthritis Register.
Ann Rheum Dis. 2015 Nov;74(11):2099-102.
17/09/2015
Yarwood A, Viatte S, Okada Y, Plenge R, Yamamoto K; BRAGGSS, RACI,, Barton A, Symmons D, Raychaudhuri S, Klareskog L, Gregersen P, Worthington J, Eyre S.
Loci associated with N-glycosylation of human IgG are not associated with rheumatoid arthritis: a Mendelian randomisation study.
Ann Rheum Dis. 2015 Sep 17. doi: 10.1136/annrheumdis-2014-207210.
08/04/2015
Schuetz P, Leuppi JD, Bingisser R, Bodmer M, Briel M, Drescher T, Duerring U, Henzen C, Leibbrandt Y, Maier S, Miedinger D, Mueller B, Scherr A, Schindler C, Stoeckli R, Viatte S, von Garnier C, Tamm M, Rutishauser J.
Prospective analysis of adrenal function in patients with acute exacerbations of COPD: The REDUCE* trial (*Reduction in the Use of Corticosteroids in Exacerbated COPD).
Eur J Endocrinol. 2015 Apr 8.
10/06/2014
Nogueira L, Cornillet M, Singwe-Ngandeu M, Viatte S, Bas S, Gabay C, Serre G.
In Black Africans with rheumatoid arthritis, ACPA recognize citrullinated fibrinogen and the derived peptides α36-50Cit38,42 and β60-74Cit60,72,74, like in Caucasians.
Clin Immunol. 2014 May-Jun;152(1-2):58-64.
10/01/2014
Orozco G, Viatte S, Bowes J, Martin P, Wilson AG, Morgan AW, Steer S, Wordsworth P, Hocking LJ; UKRAG consortium; WTCCC consortium; BRAGGSS consortium, Barton A, Worthington J, Eyre S.
Novel RA susceptibility locus at 22q12 identified in an extended UK genome wide association study.
Arthritis Rheumatol. 2014 Jan;66(1):24-30.
09/12/2013
Yarwood A, Viatte S, Plant D, Morgan AW, Isaacs J, Wilson AG, Hyrich K, Eyre S, Barton A; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS).
Testing the role of vitamin D in response to antitumour necrosis factor α therapy in a UK cohort: a Mendelian randomisation approach.
Ann Rheum Dis. 2013 Dec 9.
08/12/2013
McAllister K, Yarwood A, Bowes J, Orozco G, Viatte S, Diogo D, Hocking LJ, Steer S, Wordsworth P, Wilson AG, Morgan AW; UK Rheumatoid Arthritis Genetics Consortium; Rheumatoid Arthritis Consortium International, Kremer J, Pappas D, Gregersen P, Klareskog L, Plenge R, Barton A, Greenberg J, Worthington J, Eyre S.
Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-analysis of genome-wide data.
Arthritis Rheum. 2013 Dec;65(12):3058-62.
26/09/2013
Lee JC, Espéli M, Anderson CA, Linterman MA, Pocock JM, Williams NJ, Roberts R, Viatte S, Fu B, Peshu N, Hien TT, Phu NH, Wesley E, Edwards C, Ahmad T, Mansfield JC, Gearry R, Dunstan S, Williams TN, Barton A, Vinuesa CG; UK IBD Genetics Consortium, Parkes M, Lyons PA, Smith KG.
Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway.
Cell. 2013 Sep 26;155(1):57-69.
16/07/2013
Fagerberg T*, Zoete V*, Viatte S, Baumgärtner-Meier P, Alves PM, Romero P, Speiser DE, Michielin O.*Joint first authors
Prediction of cross-recognition of peptide-HLA-A2 by Melan-A-specific CTLs using three dimentional quantitative structure-activity relationships.
PLoS One. 2013 Jul 16;8(7):e65590.
03/06/2013
Leuppi JD*, Schuetz P*, Bingisser R, Bodmer M, Briel M, Drescher T, Duerring U, Henzen C, Leibbrandt Y, Maier S, Miedinger D, Mueller B, Scherr A, Schindler C, Stoeckli R, Viatte S, von Garnier C, Tamm M, Rutishauser J. *Joint first authors
Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial.
JAMA. 2013 Jun 5;309(21):2223-31.
10/12/2012
Eyre S*, Bowes J*, Diogo D*, Lee A, Barton A, Martin P, Zhernakova A, Stahl E, Viatte S, McAllister K, Amos CI, Padyukov L, Toes RE, Huizinga TW, Wijmenga C, Trynka G, Franke L, Westra HJ, Alfredsson L, Hu X, Sandor C, de Bakker PI, Davila S, Khor CC, Heng KK, Andrews R, Edkins S, Hunt SE, Langford C, Symmons D; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate; Wellcome Trust Case Control Consortium, Concannon P, Onengut-Gumuscu S, Rich SS, Deloukas P, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Arlsetig L, Martin J, Rantapää-Dahlqvist S, Plenge RM, Raychaudhuri S, Klareskog L, Gregersen PK, Worthington J. *Joint first authors
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
Nat Genet. 2012 Dec;44(12):1336-40.
10/04/2012
Genevay S, Finckh A, Zufferey P, Viatte S, Balagué F, Gabay C.
Adalimumab in acute sciatica reduces the long-term need for surgery: a 3-year follow-up of a randomised double-blind placebo-controlled trial.
Ann Rheum Dis. 2012 Apr;71(4):560-2.
18/10/2010
Schuetz P, Leuppi JD, Tamm M, Briel M, Bingisser R, Dürring U, Müller B, Schindler C, Viatte S, Rutishauser J.
Short versus conventional term glucocorticoid therapy in acute exacerbation of chronic obstructive pulmonary disease – the “REDUCE” trial.
Swiss Med Wkly. 2010 Oct 18;140:w13109. doi: 10.4414/smw.2010.13109.
10/08/2010
Genevay S, Viatte S, Finck A, Zufferey P, Balagué F, Gabay C.
Adalimumab in severe and acute sciatica: A multicentre, randomised, double-blind, placebo-controlled trial.
Arthritis Rheum. 2010 Aug;62(8):2339-46.
10/10/2009
Bas S, Neff L, Viatte S, Vuillet M, Spenato U, Guerne PA, Michel M, Tiercy JM, Butrimiene I, Gabay C.
Relationship between gamma-interferon and interleukin-17 in Chlamydia trachomatis reactive arthritis.
Clin and Exp Rheumatol. 2009 Sep-Oct;27(5):885-6.
10/03/2009
Palmer G, Talabot-Ayer D, Lamacchia C, Toy D, Seemayer CA, Viatte S, Finckh A, Smith DE, Gabay C.
Inhibition of IL-33 Signaling Attenuates the Severity of Experimental Arthritis.
Arthritis Rheum. 2009 Mar;60(3):738-49.
27/06/2008
Alves PM, Lévy N, Stevenson BJ, Bouzourene H, Theiler G, Bricard G, Viatte S, Ayyoub M, Vuilleumier H, Givel JC, Rimoldi D, Speiser DE, Jongeneel CV, Romero PJ, Lévy F.
Identification of tumor-associated antigens by large-scale analysis of genes expressed in human colorectal cancer.
Cancer Immun. 2008 Jun 27;8:11.
10/11/2007
Alves PM, Viatte S, Fagerberg T, Michielin O, Bricard G, Bouzourene H, Vuilleumier H, Kruger T, Givel JC, Levy F, Speiser DE, Cerottini JC, Romero P.
Immunogenicity of the carcinoembryonic antigen derived peptide 694 in HLA-A2 healthy donors and colorectal carcinoma patients.
Cancer Immunol Immunother. 2007 Nov;56(11):1795-805.
10/06/2007
Alves PM, Levy N, Bouzourene H, Viatte S, Bricard G, Ayyoub M, Vuilleumier H, Givel JC, Halkic N, Speiser DE, Romero P, Levy F.
Molecular and immunological evaluation of the expression of cancer/testis gene products in human colorectal cancer.
Cancer Immunol Immunother. 2007 Jun;56(6):839-47.
01/01/2004
Miklos DB, Kim HT, Zorn E, Hochberg EP, Guo L, Mattes-Ritz A, Viatte S, Soiffer RJ, Antin JH, Ritz J.
Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donors.
Blood. 2004 Jan 1;103(1):353-9.