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Systematic review and independent validation…
Sharma SD, Hum RM, Nair N, Marshall L, Storrie A, Bowes J, MacGregor A, Yates M, Morris AP, Verstappen S, Barton A, van Steenbergen H, Knevel R, van der Helm-van Mil A, Viatte S.
Systematic review and independent validation of genetic factors of radiographic outcome in rheumatoid arthritis identifies a genome-wide association with CARD9.
Ann Rheum Dis. 2025 Sep;84(9):1469-1483.
Impact: the Viatte lab, working with our international collaborators, has conducted a systematic review and validation of all know genetic associations with disease severity in rheumatoid arthritis outside the HLA and demonstrated that very few genetic determinants of disease susceptibility are shared with genetic determinants of disease outcome. This finding supports the principle that different genetic factors underlie transition to different clinical stages of autoimmune diseases. This contribution has important implications for the choice of genetic markers to include in the calculation of Polygenic Risk Scores (PRS) for stratified medicine in general.